Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 14/20 | 0.51 |
| ▸ | KDR | P35968 | 7/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 13/20 | 0.40 |
| ▸ | SRC | P12931 | 13/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2632884 | 0.78 | LCK (0.57) | LCKKDRJAK3MAPK14CSNK1D | |
| SCHEMBL610225 | 0.78 | EGFR (0.57) | LCKKDRJAK3MAPK14CSNK1D | |
| SCHEMBL30912753 | 0.78 | EGFR (0.57) | LCKKDRJAK3MAPK14CSNK1D | |
| SCHEMBL14146496 | 0.77 | KDM4E (0.49) | LCKKDRJAK3MAPK14EGFR | |
| Benzene SCHEMBL28800797 | 0.74 | EGFR (0.53) | LCKKDRJAK3MAPK14CSNK1D | |
| SCHEMBL28798252 | 0.74 | BACE1 (0.55) | LCKKDRJAK3MAPK14CSNK1D | |
| SCHEMBL46742 | 0.74 | BACE1 (0.55) | LCKKDRJAK3MAPK14CSNK1D | |
| SCHEMBL2130969 | 0.74 | PIK3CG (0.53) | LCKKDRJAK3MAPK14CSNK1D | |
| SCHEMBL27957917 | 0.74 | KDR (0.49) | LCKKDRJAK3MAPK14CSNK1D | |
| SCHEMBL15679285 | 0.74 | LCK (0.49) | LCKKDRJAK3MAPK14CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |