Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.32 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14713996 | 1.00 | GBA1 (0.50) | GBA1CA1CA2CA4TRPA1 | |
| SCHEMBL16885307 | 0.82 | TRPA1 (0.43) | GBA1CA1CA2CA4TRPA1 | |
| SCHEMBL7875684 | 0.82 | TRPA1 (0.43) | GBA1CA1CA2CA4TRPA1 | |
| SCHEMBL16885318 | 0.82 | TRPA1 (0.43) | GBA1CA1CA2CA4TRPA1 | |
| SCHEMBL16885317 | 0.82 | TRPA1 (0.43) | GBA1CA1CA2CA4TRPA1 | |
| SCHEMBL16885315 | 0.82 | TRPA1 (0.43) | GBA1CA1CA2CA4TRPA1 | |
| SCHEMBL3480513 | 0.81 | GBA1 (0.47) | GBA1CA1CA2CA4TRPA1 | |
| SCHEMBL1132298 | 0.79 | CA1 (0.43) | GBA1CA1CA2CA4TRPA1 | |
| SCHEMBL6907590 | 0.77 | CA1 (0.42) | GBA1CA1CA2CA4TRPA1 | |
| SCHEMBL6905830 | 0.77 | CA1 (0.42) | GBA1CA1CA2CA4TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |