Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.62 |
| ▸ | KIT | P10721 | 5/20 | 0.62 |
| ▸ | LCK | P06239 | 4/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 3/20 | 0.57 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5492668 | 0.94 | MAPK14 (0.61) | MAPK14KITLCKKDRMAPK9 | |
| SCHEMBL5489360 | 0.93 | MAPK14 (0.60) | MAPK14KITLCKKDRMAPK9 | |
| SCHEMBL5492442 | 0.93 | MAPK14 (0.60) | MAPK14KITLCKKDRMAPK9 | |
| SCHEMBL5495695 | 0.93 | MAPK14 (0.62) | MAPK14KITLCKKDRMAPK9 | |
| SCHEMBL14568538 | 0.89 | MAPK14 (0.59) | MAPK14KITLCKKDRMAPK9 | |
| SCHEMBL14715603 | 0.89 | MAPK14 (0.59) | MAPK14KITLCKKDRMAPK9 | |
| SCHEMBL14569069 | 0.89 | MAPK14 (0.59) | MAPK14KITLCKKDRMAPK9 | |
| SCHEMBL5489307 | 0.89 | MAPK14 (0.59) | MAPK14KITLCKKDRMAPK9 | |
| SCHEMBL5498290 | 0.89 | MAPK14 (0.59) | MAPK14KITLCKKDRMAPK9 | |
| SCHEMBL5489357 | 0.89 | MAPK14 (0.56) | MAPK14KITLCKKDRMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |