Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.56 |
| ▸ | KDR | P35968 | 10/20 | 0.56 |
| ▸ | KIT | P10721 | 10/20 | 0.56 |
| ▸ | LCK | P06239 | 8/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5492442 | 0.89 | MAPK14 (0.60) | MAPK14KDRKITLCKMAPK9 | |
| SCHEMBL14724658 | 0.89 | MAPK14 (0.62) | MAPK14KDRKITLCKMAPK9 | |
| SCHEMBL5492668 | 0.88 | MAPK14 (0.61) | MAPK14KDRKITLCKMAPK9 | |
| SCHEMBL5495695 | 0.87 | MAPK14 (0.62) | MAPK14KDRKITLCKMAPK9 | |
| SCHEMBL5489360 | 0.87 | MAPK14 (0.60) | MAPK14KDRKITLCKMAPK9 | |
| SCHEMBL5489307 | 0.85 | MAPK14 (0.59) | MAPK14KDRKITLCKMAPK9 | |
| SCHEMBL14569069 | 0.85 | MAPK14 (0.59) | MAPK14KDRKITLCKMAPK9 | |
| SCHEMBL14568538 | 0.85 | MAPK14 (0.59) | MAPK14KDRKITLCKMAPK9 | |
| SCHEMBL14715603 | 0.85 | MAPK14 (0.59) | MAPK14KDRKITLCKMAPK9 | |
| SCHEMBL14568551 | 0.84 | MAPK14 (0.56) | MAPK14KDRKITLCKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | claimed |