Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 5/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.39 |
| ▸ | MERTK | Q12866 | 5/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 5/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.39 |
| ▸ | DNM2 | P50570 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498763 | 0.87 | FGFR1 (0.53) | KMT2AATMFGFR1EGFRFLT3 | |
| SCHEMBL5495588 | 0.86 | FLT3 (0.47) | KMT2AATMEGFRFLT3TRIM58 | |
| SCHEMBL5492795 | 0.86 | KMT2A (0.56) | KMT2AATMFGFR1L3MBTL1FLT3 | |
| SCHEMBL5496280 | 0.85 | LMNA (0.44) | KMT2AATMHTT | |
| SCHEMBL5505032 | 0.83 | EGFR (0.53) | EGFRFLT3DNM2 | |
| SCHEMBL27857025 | 0.83 | MERTK (0.45) | FGFR1EGFRTLR8FLT3TYRO3 | |
| SCHEMBL27873830 | 0.82 | EGFR (0.47) | EGFRTLR8FLT3TYRO3MERTK | |
| SCHEMBL5495483 | 0.82 | BRAF (0.43) | — | |
| SCHEMBL5494492 | 0.81 | BRD4 (0.39) | KMT2AATMCCNCHTTCDK8 | |
| SCHEMBL27857054 | 0.80 | NPY1R (0.44) | FGFR1EGFRTLR8FLT3TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |
| CN-102491949-A | Method for synthesizing 2-(N-alkyl) aminopyrimidine derivatives by means of N-alkylation | UNIV NANJING SCIENCE & TECH | 2012-06-13 | — | — | CN | disclosed |