Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 18/20 | 0.77 |
| ▸ | KDR | P35968 | 18/20 | 0.77 |
| ▸ | MAPK14 | Q16539 | 18/20 | 0.77 |
| ▸ | JAK3 | P52333 | 12/20 | 0.67 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.66 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.66 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | TYK2 | P29597 | 1/20 | 0.62 |
| ▸ | SYK | P43405 | 1/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.62 |
| ▸ | BTK | Q06187 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.61 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14724709 | 0.88 | MAPK14 (0.78) | LCKKDRMAPK14JAK3RIPK1 | |
| SCHEMBL5489606 | 0.87 | LCK (1.00) | LCKKDRMAPK14JAK3RIPK1 | |
| SCHEMBL5490716 | 0.86 | LCK (0.88) | LCKKDRMAPK14JAK3RIPK1 | |
| SCHEMBL5496829 | 0.86 | LCK (1.00) | LCKKDRMAPK14JAK3RIPK1 | |
| SCHEMBL5494466 | 0.85 | LCK (0.88) | LCKKDRMAPK14JAK3RIPK1 | |
| SCHEMBL5498449 | 0.85 | LCK (0.74) | LCKKDRMAPK14JAK3RIPK1 | |
| SCHEMBL14715479 | 0.84 | KDR (0.70) | LCKKDRMAPK14JAK3RIPK1 | |
| SCHEMBL5491491 | 0.84 | MAPK14 (0.85) | LCKKDRMAPK14JAK3RIPK1 | |
| SCHEMBL5489126 | 0.83 | LCK (0.87) | LCKKDRMAPK14JAK3RIPK1 | |
| SCHEMBL5498034 | 0.83 | LCK (0.75) | LCKKDRMAPK14JAK3RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |