Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.78 |
| ▸ | LCK | P06239 | 15/20 | 0.78 |
| ▸ | KDR | P35968 | 15/20 | 0.78 |
| ▸ | JAK3 | P52333 | 9/20 | 0.78 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.71 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.71 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 2/20 | 0.66 |
| ▸ | KIT | P10721 | 2/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | SYK | P43405 | 1/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.66 |
| ▸ | BTK | Q06187 | 1/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14724713 | 0.88 | LCK (0.77) | MAPK14LCKKDRJAK3RIPK1 | |
| SCHEMBL5494923 | 0.88 | MAPK14 (0.75) | MAPK14LCKKDRJAK3RIPK1 | |
| SCHEMBL5490497 | 0.88 | LCK (1.00) | MAPK14LCKKDRJAK3RIPK1 | |
| SCHEMBL5494861 | 0.87 | LCK (0.89) | MAPK14LCKKDRJAK3RIPK1 | |
| SCHEMBL5494716 | 0.86 | MAPK14 (0.76) | MAPK14LCKKDRJAK3RIPK1 | |
| SCHEMBL5496169 | 0.85 | MAPK14 (0.91) | MAPK14LCKKDRJAK3RIPK1 | |
| SCHEMBL5497210 | 0.84 | MAPK14 (0.72) | MAPK14LCKKDRJAK3RIPK1 | |
| SCHEMBL5494376 | 0.84 | LCK (0.75) | MAPK14LCKKDRJAK3RIPK1 | |
| SCHEMBL5494152 | 0.84 | RIPK1 (0.76) | MAPK14LCKKDRJAK3RIPK1 | |
| SCHEMBL5494933 | 0.84 | LCK (0.77) | MAPK14LCKKDRJAK3RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |