Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087294 | 0.90 | MEN1 (0.44) | MEN1KMT2AKDRLMNAKDM4E | |
| SCHEMBL6087302 | 0.90 | MEN1 (0.44) | MEN1KMT2AKDRLMNAKDM4E | |
| SCHEMBL6089358 | 0.87 | LRRK2 (0.51) | MEN1KMT2AKDRALDH1A1HTT | |
| SCHEMBL6089352 | 0.87 | LRRK2 (0.51) | MEN1KMT2AKDRALDH1A1HTT | |
| SCHEMBL14725091 | 0.86 | ALDH1A1 (0.46) | MEN1KMT2AKDRLMNAKDM4E | |
| SCHEMBL6087676 | 0.86 | ALDH1A1 (0.46) | MEN1KMT2AKDRLMNAKDM4E | |
| SCHEMBL6087668 | 0.86 | ALDH1A1 (0.46) | MEN1KMT2AKDRLMNAKDM4E | |
| SCHEMBL6087719 | 0.85 | POLB (0.47) | KMT2AALDH1A1SMN1; SMN2PAK1 | |
| SCHEMBL14725080 | 0.85 | HPGD (0.49) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6086632 | 0.85 | HPGD (0.49) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490356-B1 | (3Z)-3-(3-HYDRO-ISOBENZOFURAN-1-YLIDENE)-1,3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2013-02-27 | — | — | EP | disclosed |