Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087431 | 0.90 | KDR (0.42) | MAPTKDM4ERAB9APOLBNPSR1 | |
| SCHEMBL6087438 | 0.90 | KDR (0.42) | MAPTKDM4ERAB9APOLBNPSR1 | |
| SCHEMBL6086850 | 0.90 | ALDH1A1 (0.43) | MAPTKDM4ERAB9APOLBNPSR1 | |
| SCHEMBL14725074 | 0.90 | ALDH1A1 (0.43) | MAPTKDM4ERAB9APOLBNPSR1 | |
| SCHEMBL6087556 | 0.89 | LRRK2 (0.51) | MAPTKDM4ERAB9AAAK1KDR | |
| SCHEMBL6087551 | 0.89 | LRRK2 (0.51) | MAPTKDM4ERAB9AAAK1KDR | |
| SCHEMBL6086359 | 0.87 | POLB (0.47) | TSHRPOLBNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6086361 | 0.87 | POLB (0.47) | TSHRPOLBNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6087269 | 0.85 | HPGD (0.49) | MAPTKDM4ETSHRPOLBALDH1A1 | |
| SCHEMBL6087266 | 0.85 | HPGD (0.49) | MAPTKDM4ETSHRPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490356-B1 | (3Z)-3-(3-HYDRO-ISOBENZOFURAN-1-YLIDENE)-1,3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2013-02-27 | — | — | EP | disclosed |