Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10978124 | 0.76 | — | — | |
| SCHEMBL27735169 | 0.76 | — | — | |
| SCHEMBL28655739 | 0.76 | ALDH1A1 (0.41) | TSHRTHRBALDH1A1ATMLMNA | |
| SCHEMBL11903057 | 0.74 | — | — | |
| SCHEMBL2777222 | 0.71 | ALDH1A1 (0.36) | TSHRTHRBALDH1A1ATMLMNA | |
| SCHEMBL26023834 | 0.70 | CPA1 (0.38) | TSHRATMCPA1 | |
| SCHEMBL27297467 | 0.70 | — | — | |
| SCHEMBL1147490 | 0.70 | ATM (0.31) | TSHRTHRBALDH1A1ATM | |
| SCHEMBL3285903 | 0.69 | — | — | |
| SCHEMBL23421107 | 0.66 | ATM (0.32) | ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407423-B2 | Compounds as inhibitors of DNA methyltransferases | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2019-09-10 | — | — | US | disclosed |
| US-20180362525-A1 | NOVEL COMPOUNDS AS INHIBITORS OF DNA METHYLTRANSFERASES | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2018-12-20 | — | — | US | disclosed |
| EP-3023423-B1 | 2 -AMINO-4 - (PYRIDIN- 2 -YL) - 5, 6 -DIHYDRO-4H- 1, 3 -OXAZINE DERIVATIVES AND THEIR USE AS BACE-1 AND/OR BACE - 2 INHIBITORS | NOVARTIS AG (CH) | 2017-05-31 | — | — | EP | disclosed |
| EP-3023423-A1 | 2 -AMINO-4 - (PYRIDIN- 2 -YL) - 5, 6 -DIHYDRO-4H- 1, 3 -OXAZINE DERIVATIVES AND THEIR USE AS BACE-1 AND/OR BACE - 2 INHIBITORS | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| CN-105519550-A | Herbicide for coniferous nursery garden | YANTAI LONGSHUN CHEMICAL TECH CO LTD | 2016-04-27 | — | — | CN | disclosed |
| CN-105519550-A | Herbicide for coniferous nursery garden | YANTAI LONGSHUN CHEMICAL TECH CO LTD | 2016-04-27 | — | — | CN | disclosed |
| US-9163011-B2 | Oxazine derivatives and their use in the treatment of disease | NOVARTIS AG (CH) | 2015-10-20 | — | — | US | disclosed |
| US-20150150877-A1 | NOVEL OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2015-06-04 | — | — | US | disclosed |
| US-20130172331-A1 | NOVEL OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG | 2013-07-04 | — | — | US | disclosed |
| WO-2013027188-A1 | 2 -AMINO-4 - (PYRIDIN- 2 -YL) - 5, 6 -DIHYDRO-4H- 1, 3 -OXAZINE DERIVATIVES AND THEIR USE AS BACE-1 AND/OR BACE - 2 INHIBITORS | NOVARTIS AG (CH) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180362525-A1 | NOVEL COMPOUNDS AS INHIBITORS OF DNA METHYLTRANSFERASES | DNMT3B, DNMT3A, DNMT1 | TSHR 2941/4885THRB 1056/4885ALDH1A1 323/4885 |
| US-20130172331-A1 | NOVEL OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | BACE2, BACE1, PSEN1 | TSHR 4491/4885THRB 2323/4885ALDH1A1 252/4885 |
| US-10407423-B2 | Compounds as inhibitors of DNA methyltransferases | DNMT3B, DNMT3A, DNMT1 | TSHR 2623/4885THRB 1090/4885ALDH1A1 367/4885 |
| US-20150150877-A1 | NOVEL OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | BACE2, BACE1, PSEN1 | TSHR 4491/4885THRB 2323/4885ALDH1A1 252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.