Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.66 |
| ▸ | BRD4 | O60885 | 4/20 | 0.62 |
| ▸ | BRD2 | P25440 | 1/20 | 0.54 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.54 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.54 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594609 | 0.89 | EZH2 (0.75) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL12180088 | 0.87 | EZH2 (0.72) | EZH2BRD4EZH1HDAC1HDAC6 | |
| SCHEMBL2595229 | 0.85 | EZH2 (0.66) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL16116270 | 0.84 | EZH2 (0.68) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL2593834 | 0.84 | EZH2 (0.73) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL18863744 | 0.84 | EZH2 (0.78) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL17970320 | 0.83 | EZH2 (0.77) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL17970299 | 0.83 | EZH2 (0.64) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL2593367 | 0.82 | EZH2 (0.68) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL31158046 | 0.82 | EZH2 (0.75) | EZH2BRD4BRD2BRD3BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536179-B2 | Indoles | GLAXOSMITHKLINE LLC (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536179-B2 | Indoles | GLAXOSMITHKLINE LLC (US) | 2013-09-17 | — | — | US | disclosed |
| US-20130053397-A1 | INDOLES | GLAXOSMITHKLINE LLC | 2013-02-28 | — | — | US | disclosed |
| US-20130053397-A1 | INDOLES | GLAXOSMITHKLINE LLC | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053397-A1 | INDOLES | IDO1, IDO2, INMT | EZH2 239/4885BRD4 177/4885BRD2 618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.