SCHEMBL14729122

SCHEMBL14729122

COc1ccc2c(c1)C(C)(C)CC21CC(C)(C)c2cc(Oc3ccc4c(c3)C(=O)N(c3ccc(S(=O)(=O)c5ccc(N6C(=O)c7ccc(C)cc7C6=O)cc5)cc3)C4=O)ccc21

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.48
MEN1 O00255 7/20 0.48
CA9 Q16790 5/20 0.47
CA12 O43570 3/20 0.47
CA1 P00915 3/20 0.47
CA2 P00918 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
GAA P10253 1/20 0.47
TDP1 Q9NUW8 2/20 0.45
MAPT P10636 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
ESR1 P03372 1/20 0.41
HTT P42858 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
BRD4 O60885 1/20 0.40
ALDH1A1 P00352 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19353682 0.92 BRD4 (0.47) KMT2AMEN1CA9CA12CA1
SCHEMBL19035925 0.88 MEN1 (0.40) KMT2AMEN1CA9CA12CA1
SCHEMBL14729117 0.87 MEN1 (0.49) KMT2AMEN1SMN1; SMN2GAAMAPT
SCHEMBL14729118 0.84 MEN1 (0.58) KMT2AMEN1CA9CA12CA1
SCHEMBL15447802 0.83 MEN1 (0.60) KMT2AMEN1CA9CA12CA1
SCHEMBL16706900 0.82 MEN1 (0.46) KMT2AMEN1SMN1; SMN2GAAMAPT
SCHEMBL19353681 0.79 BRD4 (0.50) KMT2AMEN1GAAMAPTNPSR1
SCHEMBL15459233 0.78 PKM (0.51) CA2SMN1; SMN2GAATDP1HTT
SCHEMBL16591494 0.78 MEN1 (0.56) KMT2AMEN1CA9CA12CA1
SCHEMBL14729133 0.77 MEN1 (0.42) KMT2AMEN1SMN1; SMN2GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2748230-B1 POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF SABIC GLOBAL TECHNOLOGIES BV (NL) 2020-12-16 EP disclosed
US-20170260333-A1 POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2017-09-14 US disclosed
US-20170260333-A1 POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2017-09-14 US disclosed
US-9688816-B2 Polyetherimide compositions and methods for the manufacture and use thereof SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2017-06-27 US disclosed
US-9688816-B2 Polyetherimide compositions and methods for the manufacture and use thereof SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2017-06-27 US disclosed
US-20150133625-A1 POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2015-05-14 US disclosed
US-20150133625-A1 POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2015-05-14 US disclosed
US-20130053489-A1 POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2013-02-28 US disclosed