SCHEMBL1472926

SCHEMBL1472926

COc1ccc([C@@H](CCCNC(=O)C2CCCC2)N2C(=O)c3cccc(N4CCN(C(C)c5ccccc5)CC4)c3C2=O)cc1OC

nearest known ligand 0.78

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 18/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1734230 1.00 UTS2R (0.78) UTS2R
SCHEMBL9884501 0.99 UTS2R (0.78) UTS2R
SCHEMBL1472289 0.99 UTS2R (0.78) UTS2R
SCHEMBL1472559 0.92 UTS2R (0.74) UTS2R
SCHEMBL1734573 0.92 UTS2R (0.74) UTS2R
Cyclopentane SCHEMBL1734638 0.91 UTS2R (0.83) UTS2R
SCHEMBL1733494 0.91 UTS2R (0.83) UTS2R
SCHEMBL1472783 0.91 UTS2R (0.74) UTS2R
SCHEMBL9884498 0.90 UTS2R (0.74) UTS2R
SCHEMBL1472020 0.90 UTS2R (0.74) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1993554-B1 UROTENSIN II RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2011-11-23 EP claimed
US-7915260-B2 Urotensin II receptor antagonists JANSSEN PHARMACEUTICA N.V. (BE) 2011-03-29 US claimed
EP-1993554-B1 UROTENSIN II RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2011-11-23 EP disclosed