Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 5/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | F2R | P25116 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14730243 | 0.94 | GPR119 (0.36) | NTRK1 | |
| SCHEMBL14730224 | 0.89 | NTRK1 (0.35) | NTRK1RETNPY5REIF2AK4KDM1A | |
| SCHEMBL14730269 | 0.88 | NTRK1 (0.37) | NTRK1RETNPY5REIF2AK4F2R | |
| SCHEMBL14723139 | 0.86 | USP30 (0.41) | NTRK1RETNPY5R | |
| SCHEMBL14723138 | 0.86 | USP30 (0.41) | NTRK1RETNPY5R | |
| SCHEMBL470608 | 0.85 | NTRK1 (0.37) | NTRK1RETNPY5RCKS1BSKP1 | |
| SCHEMBL14730318 | 0.84 | NTRK1 (0.34) | NTRK1NPY5REIF2AK4HDAC6NR1H2 | |
| SCHEMBL14730266 | 0.84 | GPR119 (0.36) | NTRK1 | |
| SCHEMBL14722527 | 0.82 | PDE4B (0.41) | NTRK1NPY5R | |
| SCHEMBL14730325 | 0.82 | NTRK1 (0.33) | NTRK1RETNPY5REIF2AK4NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026587-A1 | 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2013-02-28 | — | — | WO | disclosed |