Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 11/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.77 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.77 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.68 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1472442 | 1.00 | ALDH1A3 (0.77) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NR4A2 | |
| SCHEMBL13325768 | 0.87 | ALDH1A3 (1.00) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NR4A2 | |
| SCHEMBL1472422 | 0.87 | NR4A2 (0.83) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NR4A2 | |
| SCHEMBL3433041 | 0.83 | ALDH1A3 (0.52) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NR4A2 | |
| SCHEMBL12970541 | 0.82 | NPC1 (0.73) | ALDH1A3ALDH1A1SLC2A1NR4A2CYP2C9 | |
| SCHEMBL16261617 | 0.81 | ALDH1A3 (1.00) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NPC1 | |
| SCHEMBL220148 | 0.81 | NR4A2 (0.60) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NR4A2 | |
| SCHEMBL1472921 | 0.81 | NR4A2 (0.51) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NR4A2 | |
| SCHEMBL1472596 | 0.81 | CYP2C9 (0.51) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NR4A2 | |
| SCHEMBL1472161 | 0.81 | ALDH1A3 (0.70) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915284-B2 | 2-aryl-6-phenylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2011-03-29 | — | — | US | claimed |
| US-20090253735-A1 | 2-ARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253735-A1 | 2-ARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | NCOR1, NR4A2, NR4A3 | ALDH1A3 1043/4885ALDH1A1 1788/4885ALDH1A2 1466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.