Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.43 |
| ▸ | GAK | O14976 | 15/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 10/20 | 0.43 |
| ▸ | COQ8A | Q8NI60 | 10/20 | 0.43 |
| ▸ | NLK | Q9UBE8 | 10/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.40 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.40 |
| ▸ | TXK | P42681 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | STK16 | O75716 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589406 | 0.87 | GAK (0.46) | EGFRGAKRIPK2COQ8ANLK | |
| SCHEMBL600967 | 0.72 | RIPK2 (0.37) | GAKRIPK2LCK | |
| SCHEMBL600385 | 0.72 | RIPK2 (0.37) | GAKRIPK2LCK | |
| SCHEMBL600708 | 0.72 | RIPK2 (0.37) | GAKRIPK2LCK | |
| SCHEMBL10106406 | 0.71 | RIPK2 (0.52) | GAKRIPK2LCK | |
| SCHEMBL10106405 | 0.71 | RIPK2 (0.52) | GAKRIPK2LCK | |
| SCHEMBL17059485 | 0.71 | RIPK2 (0.53) | EGFRRIPK2BRAF | |
| SCHEMBL2594532 | 0.68 | GAK (0.52) | EGFRGAKRIPK2COQ8ANLK | |
| SCHEMBL2594988 | 0.67 | GAK (0.48) | EGFRGAKRIPK2COQ8ANLK | |
| SCHEMBL12496271 | 0.66 | RIPK2 (0.55) | EGFRGAKRIPK2COQ8ANLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053375-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053375-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | ABL1, MAP3K2, MAP4K2 | EGFR 473/4885GAK 162/4885RIPK2 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.