Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 4/20 | 0.55 |
| ▸ | BRAF | P15056 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24697509 | 0.90 | KIT (0.57) | KITBRAFNPC1RAB9AMAPT | |
| SCHEMBL25840028 | 0.90 | KIT (0.57) | KITBRAFNPC1RAB9AMAPT | |
| SCHEMBL12518236 | 0.88 | KIT (0.51) | KITBRAFNPC1RAB9AMAPT | |
| SCHEMBL16241756 | 0.87 | KIT (0.70) | KIT | |
| SCHEMBL25840270 | 0.83 | RAB9A (0.56) | KITBRAFNPC1RAB9AMAPT | |
| SCHEMBL12871531 | 0.80 | KIT (0.84) | KITBRAFEGFR | |
| SCHEMBL26037408 | 0.80 | TRPV1 (0.54) | KITNPC1RAB9AMAPTHTT | |
| SCHEMBL18298084 | 0.80 | KIT (0.71) | KITBRAFNPC1RAB9AMAPT | |
| SCHEMBL13660025 | 0.80 | KIT (0.67) | KITBRAFHTTEGFR | |
| SCHEMBL25815447 | 0.78 | MAPT (0.51) | KITBRAFNPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |