Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PRF1 | P14222 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589152 | 0.88 | PRF1 (0.47) | KDM4ELMNAPRF1CYP3A4PDE4D | |
| SCHEMBL14737690 | 0.85 | KDM4E (0.49) | KDM4ELMNAPRF1CYP3A4PDE4D | |
| SCHEMBL14738209 | 0.84 | PDE4D (0.46) | KDM4ELMNAPRF1CYP3A4PDE4D | |
| SCHEMBL14738144 | 0.84 | PDE4D (0.48) | KDM4ELMNAPRF1CYP3A4PDE4D | |
| SCHEMBL14737293 | 0.83 | PDE4D (0.46) | KDM4ELMNAPRF1CYP3A4PDE4D | |
| SCHEMBL14737770 | 0.83 | PDE4D (0.47) | KDM4ELMNAPRF1CYP3A4PDE4D | |
| SCHEMBL2593168 | 0.83 | CYP3A4 (0.51) | KDM4ELMNAPRF1CYP3A4PDE4D | |
| SCHEMBL2596115 | 0.83 | CYP3A4 (0.51) | KDM4ELMNAPRF1CYP3A4PDE4D | |
| SCHEMBL14735883 | 0.83 | PDE4D (0.46) | KDM4ELMNAPRF1CYP3A4PDE4D | |
| SCHEMBL7716197 | 0.82 | PRF1 (0.46) | KDM4ELMNAPRF1CYP3A4PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |