Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PRF1 | P14222 | 5/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599593 | 0.88 | PRF1 (0.47) | CYP3A4LMNAKDM4EPRF1PDE4D | |
| SCHEMBL2589152 | 0.85 | PRF1 (0.47) | CYP3A4LMNAKDM4EPRF1PDE4D | |
| SCHEMBL2591436 | 0.85 | PDE4D (0.48) | CYP3A4LMNAKDM4EPRF1PDE4D | |
| SCHEMBL2593168 | 0.85 | CYP3A4 (0.51) | CYP3A4LMNAKDM4EPRF1PDE4D | |
| SCHEMBL2581714 | 0.85 | LMNA (0.55) | CYP3A4LMNAKDM4EPRF1PDE4D | |
| SCHEMBL7716197 | 0.84 | PRF1 (0.46) | CYP3A4LMNAKDM4EPRF1PDE4D | |
| SCHEMBL2592360 | 0.84 | PRF1 (0.51) | CYP3A4LMNAKDM4EPRF1PDE4D | |
| SCHEMBL2589787 | 0.83 | PRF1 (0.48) | CYP3A4LMNAKDM4EPRF1PDE4D | |
| SCHEMBL2585895 | 0.83 | PDE4D (0.48) | CYP3A4LMNAKDM4EPRF1PDE4D | |
| SCHEMBL2593958 | 0.83 | PDE4D (0.47) | CYP3A4LMNAKDM4EPRF1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |