Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735298 | 0.83 | TDP1 (0.46) | ACE2GRM1KMT2AMEN1CYP1A2 | |
| SCHEMBL14735229 | 0.82 | LMNA (0.44) | ACE2GRM1KMT2AMEN1CYP1A2 | |
| SCHEMBL12583708 | 0.79 | LMNA (0.56) | TSHRACE2GRM1KMT2AMEN1 | |
| SCHEMBL9185164 | 0.79 | LMNA (0.56) | TSHRACE2GRM1KMT2AMEN1 | |
| SCHEMBL7598306 | 0.79 | TSHR (0.59) | TSHRACE2GRM1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL986200 | 0.78 | LMNA (0.55) | TSHRACE2GRM1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6557925 | 0.78 | LMNA (0.55) | TSHRACE2GRM1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL986198 | 0.78 | LMNA (0.55) | TSHRACE2GRM1KMT2AMEN1 | |
| SCHEMBL5988715 | 0.77 | ANPEP (0.49) | TSHRKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL20768593 | 0.73 | TSHR (0.52) | TSHRACE2GRM1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598355-B2 | Amide compound | ASTELLAS PHARMA INC. (JP) | 2013-12-03 | — | — | US | disclosed |
| EP-2565191-A1 | 4-(Indol-7-ylcarbonylaminomethyl)cyclohexanecarboxylic acid derivatives as EP4 receptor antagonists useful for the treatment of chronic renal failure or diabetic nephropathy | Astellas Pharma Inc. (JP) | 2013-03-06 | — | — | EP | disclosed |