Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 5/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722719 | 0.89 | PTGS1 (0.46) | PTK2PTK2BPTGS1KDM4EMEN1 | |
| SCHEMBL3535023 | 0.88 | MAPK14 (0.43) | MAPK14MAPK9DDR2MAPK13MAPK12 | |
| SCHEMBL14735591 | 0.83 | MAPK14 (0.62) | MAPK14MAPK9DDR2MAPK13MAPK12 | |
| SCHEMBL3531298 | 0.82 | PTK2 (0.62) | MAPK14MAPK9DDR2MAPK13MAPK12 | |
| SCHEMBL3532225 | 0.77 | PTGS1 (0.48) | PTK2PTK2BPTGS1KDM4EMEN1 | |
| SCHEMBL3530620 | 0.77 | PTK2 (0.45) | MAPK14MAPK9DDR2MAPK13MAPK12 | |
| SCHEMBL14735558 | 0.75 | MAPK14 (0.55) | MAPK14MAPK9DDR2MAPK13MAPK12 | |
| SCHEMBL3535452 | 0.75 | PTK2 (0.46) | MAPK14MAPK9DDR2MAPK13MAPK12 | |
| SCHEMBL3532936 | 0.73 | MAPK14 (0.54) | MAPK14MAPK9DDR2KDM4EMEN1 | |
| SCHEMBL2210314 | 0.73 | MAPK14 (0.62) | MAPK14MAPK9DDR2MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912998-B1 | PYRAZOLE DERIVATIVES HAVING TYROSINKINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2013-03-06 | — | — | EP | claimed |
| EP-1912998-B1 | PYRAZOLE DERIVATIVES HAVING TYROSINKINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2013-03-06 | — | — | EP | disclosed |