Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | RET | P07949 | 5/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.41 |
| ▸ | FLT1 | P17948 | 4/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.41 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.41 |
| ▸ | SLK | Q9H2G2 | 4/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.41 |
| ▸ | KIT | P10721 | 4/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532390 | 0.90 | PTGS1 (0.44) | PTK2PTK2BAURKBAURKAIKBKE | |
| SCHEMBL3531298 | 0.86 | PTK2 (0.62) | PTK2PTK2BAURKBAURKAIKBKE | |
| SCHEMBL3534410 | 0.84 | PTK2 (0.64) | PTK2PTK2BMAPK9MAPK14KIT | |
| SCHEMBL3535452 | 0.82 | PTK2 (0.46) | PTK2PTK2BAURKBAURKAIKBKE | |
| SCHEMBL3535023 | 0.79 | MAPK14 (0.43) | PTK2PTK2BMAPK9MAPK14KDR | |
| SCHEMBL3535077 | 0.79 | MAPK14 (0.48) | MAPK9MAPK14KDRKITMAPK13 | |
| SCHEMBL3539718 | 0.78 | PTK2 (0.72) | PTK2PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3535550 | 0.77 | PTK2 (0.64) | PTK2PTK2BMAPK14KITMAPK13 | |
| SCHEMBL14735574 | 0.77 | MAPK14 (0.42) | PTK2PTK2BMAPK9MAPK14MAPK13 | |
| SCHEMBL3531837 | 0.77 | PTK2 (0.57) | PTK2PTK2BMAPK9MAPK14KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912998-B1 | PYRAZOLE DERIVATIVES HAVING TYROSINKINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2013-03-06 | — | — | EP | claimed |
| US-7662827-B2 | Pyrazole derivatives having tyrosine kinase inhibitory activity | MERCK PATENT GMBH (DE) | 2010-02-16 | — | — | US | claimed |
| US-7662827-B2 | Pyrazole derivatives having tyrosine kinase inhibitory activity | MERCK PATENT GMBH (DE) | 2010-02-16 | — | — | US | disclosed |
| US-20080207647-A1 | Pyrazole Derivatives Having Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207647-A1 | Pyrazole Derivatives Having Tyrosine Kinase Activity | TIE1, FER, ROS1 | PTK2 152/4885PTK2B 24/4885AURKB 261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.