Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 5/20 | 0.47 |
| ▸ | CDK7 | P50613 | 4/20 | 0.47 |
| ▸ | CDK9 | P50750 | 4/20 | 0.47 |
| ▸ | INSR | P06213 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29904751 | 0.85 | CDK7 (0.61) | ALKCDK7CDK9INSRMET | |
| SCHEMBL375003 | 0.85 | CDK7 (0.61) | ALKCDK7CDK9INSRMET | |
| SCHEMBL12780295 | 0.83 | ALK (0.48) | ALKCDK7CDK9INSRMET | |
| SCHEMBL12856163 | 0.83 | ALK (0.51) | ALKCDK7CDK9INSRMET | |
| SCHEMBL375360 | 0.83 | ZAP70 (0.61) | ALKCDK7CDK9INSRMET | |
| SCHEMBL375824 | 0.82 | PTK2 (0.46) | ALKCDK7CDK9INSRMET | |
| SCHEMBL375418 | 0.79 | PIN1 (0.59) | ALKCDK7CDK9INSRMET | |
| Benzamide SCHEMBL2061396 | 0.76 | ALK (0.52) | ALKCDK7CDK9INSRMET | |
| SCHEMBL375081 | 0.75 | ALK (0.52) | ALKCDK7CDK9INSRMET | |
| SCHEMBL1018125 | 0.74 | ALK (0.53) | ALKCDK7CDK9METAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |