Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 18/20 | 0.53 |
| ▸ | DRD2 | P14416 | 10/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 16/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735696 | 0.90 | HTR2A (0.59) | HTR2ADRD2HTR1ADRD3 | |
| SCHEMBL1966050 | 0.87 | DRD3 (0.63) | HTR2ADRD2HTR1ADRD3 | |
| SCHEMBL1966047 | 0.87 | DRD3 (0.63) | HTR2ADRD2HTR1ADRD3 | |
| SCHEMBL13448229 | 0.87 | DRD3 (0.63) | HTR2ADRD2HTR1ADRD3 | |
| SCHEMBL3454089 | 0.87 | HTR2A (0.63) | HTR2ADRD2DRD3 | |
| SCHEMBL1969062 | 0.87 | HTR2A (0.63) | HTR2ADRD2DRD3 | |
| SCHEMBL11904453 | 0.82 | HTR2A (0.51) | HTR2ADRD2HTR1ADRD3 | |
| SCHEMBL1969067 | 0.82 | HTR2A (0.58) | HTR2ADRD2HTR1ADRD3 | |
| SCHEMBL3454316 | 0.82 | HTR2A (0.58) | HTR2ADRD2HTR1ADRD3 | |
| SCHEMBL3453560 | 0.81 | HTR2A (0.65) | HTR2ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334657-B1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | claimed |