Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 20/20 | 0.59 |
| ▸ | DRD3 | P35462 | 18/20 | 0.59 |
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735678 | 0.90 | HTR2A (0.53) | HTR2ADRD3DRD2HTR1A | |
| SCHEMBL1969941 | 0.87 | HTR2A (0.76) | HTR2ADRD3DRD2 | |
| SCHEMBL1969943 | 0.87 | HTR2A (0.76) | HTR2ADRD3DRD2 | |
| SCHEMBL11904453 | 0.87 | HTR2A (0.51) | HTR2ADRD3DRD2HTR1A | |
| SCHEMBL15859557 | 0.87 | HTR2A (0.78) | HTR2ADRD3 | |
| SCHEMBL1966090 | 0.87 | HTR2A (0.66) | HTR2ADRD3DRD2 | |
| SCHEMBL3453157 | 0.87 | HTR2A (0.66) | HTR2ADRD3DRD2 | |
| SCHEMBL13448220 | 0.87 | HTR2A (0.66) | HTR2ADRD3DRD2 | |
| SCHEMBL1968713 | 0.84 | HTR2A (0.74) | HTR2ADRD3DRD2HTR1A | |
| SCHEMBL3453811 | 0.84 | HTR2A (0.74) | HTR2ADRD3DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334657-B1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | claimed |