Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675795 | 0.83 | PLK1 (0.52) | PLK1BRD4BRDTTTK | |
| SCHEMBL12365396 | 0.70 | PLK1 (0.70) | PLK1BRD4BRDTTTK | |
| SCHEMBL3696410 | 0.69 | PLK1 (0.35) | PLK1BRD4BRDTTTK | |
| SCHEMBL4552291 | 0.67 | PLK1 (0.65) | PLK1BRD4BRDT | |
| SCHEMBL4551690 | 0.65 | LRRK2 (0.59) | PLK1BRD4BRDTTTK | |
| SCHEMBL2360464 | 0.61 | IDH1 (0.40) | PLK1BRD4BRDTTTK | |
| SCHEMBL24028163 | 0.55 | PTGDR2 (0.49) | — | |
| SCHEMBL134754 | 0.55 | RECQL (0.67) | — | |
| SCHEMBL2958828 | 0.55 | RECQL (0.60) | — | |
| SCHEMBL16959963 | 0.54 | ALDH1A1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2564850-A1 | Polo-like kinase inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2013-03-06 | — | — | EP | disclosed |