Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | IL1B | P01584 | 2/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2577780 | 0.94 | KCNH2 (0.45) | KCNH2IL1BWNT3AGSK3B | |
| SCHEMBL2575025 | 0.90 | KCNH2 (0.45) | KCNH2IL1B | |
| SCHEMBL2562548 | 0.89 | KCNH2 (0.47) | KCNH2IL1BGSK3B | |
| SCHEMBL14998315 | 0.89 | KCNH2 (0.47) | KCNH2IL1BGSK3B | |
| SCHEMBL14735815 | 0.87 | KCNH2 (0.45) | KCNH2WNT3AGSK3B | |
| SCHEMBL16524179 | 0.86 | KCNH2 (0.42) | KCNH2IL1BWNT3A | |
| SCHEMBL14998309 | 0.86 | KCNH2 (0.42) | KCNH2IL1BWNT3A | |
| SCHEMBL2576565 | 0.85 | KCNH2 (0.44) | KCNH2WNT3A | |
| SCHEMBL17685245 | 0.85 | KCNH2 (0.48) | KCNH2GSK3B | |
| SCHEMBL14734717 | 0.85 | KCNH2 (0.51) | KCNH2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563365-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2016-04-20 | — | — | EP | claimed |
| US-8969346-B2 | Amino-pyridazine skeletal muscle modulators | CYTOKINETICS, INC. (US) | 2015-03-03 | — | — | US | claimed |
| EP-2563365-A1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | Cytokinetics, Inc. (US) | 2013-03-06 | — | — | EP | disclosed |