Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 10/20 | 0.82 |
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.76 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.68 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15748760 | 0.91 | IMPDH2 (0.68) | IMPDH2AAK1ROCK2ROCK1IMPDH1 | |
| SCHEMBL15748731 | 0.91 | IMPDH2 (0.68) | IMPDH2AAK1ROCK2ROCK1IMPDH1 | |
| SCHEMBL1475741 | 0.90 | IMPDH2 (1.00) | IMPDH2AAK1ROCK2ROCK1IMPDH1 | |
| SCHEMBL15741685 | 0.90 | IMPDH2 (0.70) | IMPDH2AAK1ROCK2ROCK1IMPDH1 | |
| SCHEMBL1472891 | 0.90 | IMPDH2 (0.85) | IMPDH2AAK1ROCK2ROCK1IMPDH1 | |
| SCHEMBL15748730 | 0.89 | IMPDH2 (0.69) | IMPDH2AAK1ROCK2ROCK1IMPDH1 | |
| SCHEMBL15748408 | 0.88 | IMPDH2 (0.67) | IMPDH2AAK1ROCK2ROCK1IMPDH1 | |
| SCHEMBL6170235 | 0.87 | IMPDH2 (0.81) | IMPDH2AAK1ROCK2ROCK1IMPDH1 | |
| SCHEMBL1472983 | 0.87 | IMPDH2 (0.68) | IMPDH2AAK1ROCK2ROCK1IMPDH1 | |
| SCHEMBL1475811 | 0.86 | IMPDH2 (1.00) | IMPDH2AAK1ROCK2ROCK1IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1127054-A4 | NOVEL INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2006-11-02 | — | — | EP | claimed |
| US-20040102497-A1 | Novel inhibitors of IMPDH enzyme | GU HENRY H (US) | 2004-05-27 | — | — | US | claimed |
| US-20040082562-A1 | Novel inhibitors of IMPDH enzyme | GU HENRY H (US) | 2004-04-29 | — | — | US | claimed |
| US-6624184-B1 | Identification of the inhibitors of IMPDH (inosine-5'-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, and | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-23 | — | — | US | claimed |
| EP-1127054-A1 | NOVEL INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-08-29 | — | — | EP | claimed |
| WO-2000026197-A9 | NOVEL INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2000-10-26 | — | — | WO | claimed |
| WO-2000026197-A1 | NOVEL INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-11 | — | — | WO | claimed |
| EP-2803357-B1 | Angiogenesis inhibitors | UNIV JOHNS HOPKINS (US) | 2020-11-18 | — | — | EP | disclosed |
| US-9642865-B2 | Angiogenesis inhibitors | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-05-09 | — | — | US | disclosed |
| US-8980930-B2 | Angiogenesis inhibitors | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-03-17 | — | — | US | disclosed |
| US-20150056267-A1 | ANGIOGENESIS INHIBITORS | UNIV JOHNS HOPKINS (US) | 2015-02-26 | — | — | US | disclosed |
| EP-2803357-A2 | Angiogenesis inhibitors | THE JOHNS-HOPKINS UNIVERSITY (US) | 2014-11-19 | — | — | EP | disclosed |
| WO-2014079850-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-30 | — | — | WO | disclosed |
| WO-2006004795-A2 | ANGIOGENESIS INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-01-12 | — | — | WO | disclosed |
| US-20040102497-A1 | Novel inhibitors of IMPDH enzyme | GU HENRY H (US) | 2004-05-27 | — | — | US | disclosed |
| US-20040082562-A1 | Novel inhibitors of IMPDH enzyme | GU HENRY H (US) | 2004-04-29 | — | — | US | disclosed |
| US-6624184-B1 | Identification of the inhibitors of IMPDH (inosine-5'-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, and | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-23 | — | — | US | disclosed |
| EP-1127054-A1 | NOVEL INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000026197-A9 | NOVEL INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2000-10-26 | — | — | WO | disclosed |
| WO-2000026197-A1 | NOVEL INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150056267-A1 | ANGIOGENESIS INHIBITORS | FLT1, VEGFA, FLT4 | IMPDH2 2862/4885AAK1 793/4885ROCK2 850/4885 |
| US-20040082562-A1 | Novel inhibitors of IMPDH enzyme | IMPDH1, IMPDH2, IMPA1 | IMPDH2 2/4885AAK1 2009/4885ROCK2 2501/4885 |
| US-20040102497-A1 | Novel inhibitors of IMPDH enzyme | IMPDH1, IMPDH2, IMPA1 | IMPDH2 2/4885AAK1 2009/4885ROCK2 2501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.