Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLM | Q9NP87 | 2/20 | 0.34 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.34 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.34 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737077 | 0.97 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDCNR2CNR1 | |
| SCHEMBL2592461 | 0.94 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDCNR2CNR1 | |
| SCHEMBL2591764 | 0.90 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDCNR2CNR1 | |
| SCHEMBL14734833 | 0.88 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDGAAHDAC4 | |
| SCHEMBL2589336 | 0.87 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDGAAHDAC4 | |
| SCHEMBL2592149 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDGAAHDAC4 | |
| SCHEMBL2584956 | 0.87 | CNR2 (0.37) | KDM4ECNR2CNR1POLMPOLK | |
| SCHEMBL2592543 | 0.86 | CNR2 (0.36) | CNR2CNR1POLMPOLKPOLL | |
| SCHEMBL2591750 | 0.85 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDGAAHDAC4 | |
| SCHEMBL14737130 | 0.85 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDGAAHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |
| US-9051290-B2 | Biaryl phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2015-06-09 | — | — | US | disclosed |
| US-9051290-B2 | Biaryl phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2015-06-09 | — | — | US | disclosed |
| US-9051290-B2 | Biaryl phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2015-06-09 | — | — | US | disclosed |
| US-20130059853-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2013-03-07 | — | — | US | disclosed |
| US-20130059853-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2013-03-07 | — | — | US | disclosed |
| US-20130059853-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059853-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | PDE3B, PDE3A, PDE4A | ALDH1A1 824/4885KDM4E 1593/4885HPGD 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.