Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11297901 | 0.85 | HDAC1 (0.50) | PTGS1PTGS2HDAC1HDAC6 | |
| SCHEMBL14736372 | 0.84 | PDE10A (0.48) | PDE10AHDAC1HDAC6GRM5 | |
| SCHEMBL14736026 | 0.83 | PDE10A (0.43) | PDE10AHDAC1HDAC6GRM5 | |
| SCHEMBL14736577 | 0.81 | PDE10A (0.48) | PDE10AHDAC1HDAC6GRM5 | |
| SCHEMBL19196265 | 0.78 | SMN1; SMN2 (0.46) | GRM5 | |
| SCHEMBL19196224 | 0.77 | RXFP1 (0.42) | GRM5 | |
| SCHEMBL19196710 | 0.71 | KMT2A (0.43) | — | |
| SCHEMBL14736136 | 0.70 | HDAC1 (0.50) | HDAC1HDAC6 | |
| SCHEMBL14736709 | 0.70 | HDAC1 (0.53) | HDAC1HDAC6 | |
| SCHEMBL25788313 | 0.69 | DPP4 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103781768-B | Pde10 regulator | 霍夫曼-拉罗奇有限公司 | 2016-08-17 | — | — | CN | disclosed |
| EP-2753604-B1 | PDE10 MODULATORS | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-8772510-B2 | PDE10 modulators | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| CN-103781768-A | PDE10 modulators | HOFFMANN LA ROCHE | 2014-05-07 | — | — | CN | disclosed |
| WO-2013034506-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-14 | — | — | WO | disclosed |
| US-20130059833-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059833-A1 | PDE10 MODULATORS | PDE10A, PDE5A, PDE2A | PDE10A 1/4885PTGS1 911/4885PTGS2 2521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.