Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18524438 | 0.91 | SYK (0.42) | SYKJAK2JAK1JAK3ADORA2A | |
| SCHEMBL14737201 | 0.85 | SYK (0.41) | SYKJAK2JAK1JAK3ADORA2A | |
| SCHEMBL14737255 | 0.84 | SYK (0.43) | SYKJAK2JAK1JAK3ADORA2A | |
| SCHEMBL14738009 | 0.79 | SYK (0.40) | SYKSCN9ACYP2C9CFTRCYP2D6 | |
| SCHEMBL14746309 | 0.77 | SYK (0.41) | SYKJAK2JAK1JAK3ADORA2A | |
| SCHEMBL14738001 | 0.75 | SYK (0.51) | SYKJAK2JAK1JAK3CYP2C9 | |
| SCHEMBL14737596 | 0.74 | SYK (0.42) | SYKJAK2JAK1JAK3CYP2C9 | |
| SCHEMBL14737520 | 0.71 | SYK (0.64) | SYKJAK2JAK1JAK3CYP2C9 | |
| SCHEMBL14739523 | 0.71 | SYK (0.38) | SYKJAK2JAK1JAK3KDM4E | |
| SCHEMBL14737207 | 0.71 | SYK (0.81) | SYKJAK2JAK1JAK3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658646-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LAROCHE INC. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | SYK, ZAP70, JAK1 | SYK 1/4885JAK2 5/4885JAK1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.