⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17996229 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL17967420 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL20609686 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL17967415 | 0.97 | — | — | |
| Trifluoroacetic Acid SCHEMBL20609718 | 0.81 | S1PR1 (0.37) | — | |
| Trifluoroacetic Acid SCHEMBL20609714 | 0.81 | S1PR1 (0.37) | — | |
| SCHEMBL20909811 | 0.75 | — | — | |
| SCHEMBL20055218 | 0.75 | — | — | |
| SCHEMBL3194522 | 0.75 | — | — | |
| SCHEMBL194540 | 0.75 | LMNA (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | claimed |
| US-8658646-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LAROCHE INC. (US) | 2014-02-25 | — | — | US | claimed |
| US-20260069602-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | ACONCAGUA BIO INC (US) | 2026-03-12 | — | — | US | disclosed |
| US-11040981-B2 | Pyrrolotriazine compounds and methods of inhibiting TAM kinases | SYROS PHARMACEUTICALS, INC. (US) | 2021-06-22 | — | — | US | disclosed |
| US-20210147431-A1 | PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES | SYROS PHARMACEUTICALS INC (US) | 2021-05-20 | — | — | US | disclosed |
| US-20200317676-A1 | PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES | SYROS PHARMACEUTICALS, INC. (US) | 2020-10-08 | — | — | US | disclosed |
| US-10696670-B2 | Fluorinated imidazo[4,5-C]quinoline derivatives as inhibitors of bromodomain containing proteins | TRILLIUM THERAPEUTICS INC. (CA) | 2020-06-30 | — | — | US | disclosed |
| US-20190202825-A1 | FLUORINATED IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS INHIBITORS OF BROMODOMAIN CONTAINING PROTEINS | TRILLIUM THERAPEUTICS INC. (CA) | 2019-07-04 | — | — | US | disclosed |
| US-10259809-B2 | Fluorinated imidazo[4,5-C]quinoline derivatives as inhibitors of bromodomain containing proteins | TRILLIUM THERAPEUTICS INC. (CA) | 2019-04-16 | — | — | US | disclosed |
| WO-2019006548-A1 | FLUORINATED 2,4-DIAMINOPYRIMIDINE COMPOUNDS AS MER TYROSINE KINASE (MERTK) INHIBITORS AND USES THEREOF | TRILLIUM THERAPEUTICS INC. (CA) | 2019-01-10 | — | — | WO | disclosed |
| US-20180016271-A1 | FLUORINATED IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS INHIBITORS OF BROMODOMAIN CONTAINING PROTEINS | TRILLIUM THERAPEUTICS INC. (CA) | 2018-01-18 | — | — | US | disclosed |
| US-20180016271-A1 | FLUORINATED IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS INHIBITORS OF BROMODOMAIN CONTAINING PROTEINS | TRILLIUM THERAPEUTICS INC. (CA) | 2018-01-18 | — | — | US | disclosed |
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |
| WO-2016123709-A1 | FLUORINATED IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS INHIBITORS OF BROMODOMAIN CONTAINING PROTEINS | TRILLIUM THERAPEUTICS INC. (CA) | 2016-08-11 | — | — | WO | disclosed |
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| US-8658646-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LAROCHE INC. (US) | 2014-02-25 | — | — | US | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2013-03-07 | — | — | US | disclosed |