SCHEMBL147377

SCHEMBL147377

COC(=O)Nc1cccc2c1Cc1ccccc1-2

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.73
NPC1 O15118 3/20 0.73
KDM4E B2RXH2 3/20 0.43
MAPK1 P28482 1/20 0.43
HTR2B P41595 2/20 0.43
HTR7 P34969 1/20 0.43
CYP1A2 P05177 1/20 0.42
ADRA2A P08913 1/20 0.42
MAOA P21397 1/20 0.42
SLC6A2 P23975 1/20 0.42
HTR2C P28335 1/20 0.42
SLC6A4 P31645 1/20 0.42
PKM P14618 1/20 0.42
CASP6 P55212 1/20 0.42
ALDH1A1 P00352 5/20 0.41
LMNA P02545 4/20 0.41
HPGD P15428 3/20 0.41
PNMT P11086 1/20 0.41
ALOX15 P16050 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11744790 0.90 RAB9A (0.59) RAB9ANPC1KDM4EMAPK1CYP1A2
SCHEMBL2673077 0.86 NPC1 (0.66) RAB9ANPC1MAPK1CYP1A2ALDH1A1
SCHEMBL27734481 0.86 NPC1 (0.66) RAB9ANPC1HTR2BHTR7CYP1A2
SCHEMBL28603754 0.86 RAB9A (0.66) RAB9ANPC1KDM4EMAPK1HTR2B
SCHEMBL144325 0.84 NPC1 (1.00) RAB9ANPC1KDM4EMAPK1HTR2B
SCHEMBL1567603 0.83 RAB9A (0.74) RAB9ANPC1KDM4EMAPK1HTR2B
SCHEMBL1156914 0.83 NPC1 (0.74) RAB9ANPC1KDM4EHTR2BHTR7
SCHEMBL20887164 0.81 NPC1 (0.71) RAB9ANPC1MAPK1HTR2BHTR7
SCHEMBL20887168 0.81 RAB9A (0.71) RAB9ANPC1MAPK1ALDH1A1LMNA
Sulfuric Acid SCHEMBL28964142 0.79 NPC1 (0.89) RAB9ANPC1KDM4EMAPK1HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114615999-B Drug antibody conjugates 法马马有限公司 2024-03-08 CN disclosed
CN-114615999-A Drug antibody conjugates 法马马有限公司 2022-06-10 CN disclosed
CN-110183461-A Cortex chalone analog and its synthesis and purposes 哈佛学院院长等 2019-08-30 CN disclosed
CN-106103452-B Cortictatin analogs, their synthesis and use 哈佛学院院长等 2019-05-21 CN disclosed
CN-109562122-A Oligonucleotides, composition and its method 波涛生命科学有限公司 2019-04-02 CN disclosed
CN-109462995-A The method and composition of bioactivator 波涛生命科学有限公司 2019-03-12 CN disclosed
CN-109136974-A One kind (sp containing C2)-N key compound preparation method 中国科学院上海有机化学研究所 2019-01-04 CN disclosed
CN-109071622-A peptide with anticancer activity IDP研发制药有限公司 2018-12-21 CN disclosed
CN-108602825-A Purine compounds having anticancer activity 中央研究院 2018-09-28 CN disclosed
CN-108135850-A MODULAR COMPOSITIONS FOR SCAVENGING SOLUBLE BIOMOLECULES AND METHODS RELATED THERETO 纳米提克斯有限责任公司 2018-06-08 CN disclosed
US-8895231-B2 Patterning process and resist composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 2014-11-25 US disclosed
US-20120058428-A1 PATTERNING PROCESS AND RESIST COMPOSITION SHIN-ETSU CHEMICAL CO., LTD. (JP) 2012-03-08 US disclosed
CN-101346468-A Amine-containing lipids and uses thereof MASSACHUSETTS INST TECHNOLOGY (US) 2009-01-14 CN disclosed
EP-0809622-A4 ANTI-INFLAMMATORY BENZOIC ACID DERIVATIVES SCIOS NOVA INC (US) 1998-07-08 EP disclosed
EP-0809622-A1 ANTI-INFLAMMATORY BENZOIC ACID DERIVATIVES SCIOS NOVA INC. (US) 1997-12-03 EP disclosed
WO-1996025383-A1 ANTI-INFLAMMATORY BENZOIC ACID DERIVATIVES SCIOS NOVA INC. (US) 1996-08-22 WO disclosed
US-4196291-A ANTHELMINTICS MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1980-04-01 US disclosed
US-4141978-A ANTHELMINTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1979-02-27 US disclosed
US-4113867-A ANTHELMINTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1978-09-12 US disclosed
US-4001411-A ANTHELMINTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1977-01-04 US disclosed