Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 18/20 | 0.55 |
| ▸ | IMPDH1 | P20839 | 13/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1473575 | 0.94 | IMPDH2 (0.56) | IMPDH2IMPDH1HDAC3HDAC4HDAC1 | |
| SCHEMBL1473279 | 0.94 | IMPDH2 (0.56) | IMPDH2IMPDH1HDAC3HDAC4HDAC1 | |
| SCHEMBL1475023 | 0.93 | IMPDH2 (0.56) | IMPDH2IMPDH1HDAC3HDAC4HDAC1 | |
| SCHEMBL1473234 | 0.92 | IMPDH2 (0.57) | IMPDH2IMPDH1HDAC3HDAC4HDAC1 | |
| SCHEMBL1473807 | 0.92 | IMPDH2 (0.55) | IMPDH2IMPDH1HDAC3HDAC4HDAC1 | |
| SCHEMBL1473172 | 0.92 | IMPDH2 (0.55) | IMPDH2IMPDH1HDAC3HDAC4HDAC1 | |
| SCHEMBL1153543 | 0.92 | IMPDH2 (0.58) | IMPDH2IMPDH1HDAC3HDAC4HDAC1 | |
| SCHEMBL1473080 | 0.91 | IMPDH2 (0.54) | IMPDH2IMPDH1HDAC3HDAC4HDAC1 | |
| SCHEMBL1473081 | 0.91 | IMPDH2 (0.54) | IMPDH2IMPDH1HDAC3HDAC4HDAC1 | |
| SCHEMBL1473851 | 0.91 | IMPDH2 (0.56) | IMPDH2IMPDH1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915255-B2 | Metabolism-modulating agents and uses therefor | VERVA PHARMACEUTICALS PTY LTD (AU) | 2011-03-29 | — | — | US | disclosed |
| EP-1786415-A1 | METABOLISM-MODULATING AGENTS AND USES THEREFOR | THE UNIVERSITY OF QUEENSLAND (AU) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006017896-A1 | METABOLISM-MODULATING AGENTS AND USES THEREFOR | THE UNIVERSITY OF QUEENSLAND (AU) | 2006-02-23 | — | — | WO | disclosed |