Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.43 |
| ▸ | PPARG | P37231 | 7/20 | 0.43 |
| ▸ | PPARD | Q03181 | 7/20 | 0.43 |
| ▸ | PPARA | Q07869 | 7/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747173 | 0.87 | LPAR3 (0.45) | LPAR3LPAR1LPAR2GPR84PPARG | |
| SCHEMBL14747177 | 0.84 | LPAR3 (0.49) | LPAR3LPAR1LPAR2GPR84PPARG | |
| SCHEMBL14770373 | 0.81 | LPAR3 (0.47) | LPAR3LPAR1LPAR2MEN1ESR1 | |
| SCHEMBL19979595 | 0.80 | CYP3A4 (0.47) | LPAR3LPAR1LPAR2TSHRMEN1 | |
| SCHEMBL14760633 | 0.77 | LPAR3 (0.47) | LPAR3LPAR1LPAR2GPR84PPARG | |
| SCHEMBL16238472 | 0.76 | LPAR3 (0.42) | LPAR3LPAR1LPAR2TSHRMEN1 | |
| SCHEMBL19979608 | 0.76 | LPAR3 (0.46) | LPAR3LPAR1LPAR2 | |
| SCHEMBL20049675 | 0.76 | LPAR3 (0.42) | LPAR3LPAR1LPAR2MEN1ESR1 | |
| SCHEMBL16238812 | 0.76 | LPAR3 (0.42) | LPAR3LPAR1LPAR2TSHRMEN1 | |
| SCHEMBL16238700 | 0.76 | LPAR3 (0.42) | LPAR3LPAR1LPAR2TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150030541-A1 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES | MNK 2011 LLC (F/K/A MALLINCKRODT INC.) | 2015-01-29 | — | — | US | disclosed |
| US-20150030541-A1 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES | MNK 2011 LLC (F/K/A MALLINCKRODT INC.) | 2015-01-29 | — | — | US | disclosed |
| US-20150030541-A1 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES | MNK 2011 LLC (F/K/A MALLINCKRODT INC.) | 2015-01-29 | — | — | US | disclosed |
| US-8889657-B2 | Nanoparticle PEG modification with H-phosphonates | MALLINCKRODT LLC (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889657-B2 | Nanoparticle PEG modification with H-phosphonates | MALLINCKRODT LLC (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889657-B2 | Nanoparticle PEG modification with H-phosphonates | MALLINCKRODT LLC (US) | 2014-11-18 | — | — | US | disclosed |
| EP-2750712-A2 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES | Mallinckrodt LLC (US) | 2014-07-09 | — | — | EP | disclosed |
| US-20130066086-A1 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES | MALLINCKRODT LLC (US) | 2013-03-14 | — | — | US | disclosed |
| US-20130066086-A1 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES | MALLINCKRODT LLC (US) | 2013-03-14 | — | — | US | disclosed |
| US-20130066086-A1 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES | MALLINCKRODT LLC (US) | 2013-03-14 | — | — | US | disclosed |
| WO-2013033438-A2 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES | MALLINCKRODT LLC (US) | 2013-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150030541-A1 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES | PHOSPHO1, PHPT1, HPSE | LPAR3 679/4885LPAR1 773/4885LPAR2 1113/4885 |
| US-20130066086-A1 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES | PHOSPHO1, PHPT1, HPSE | LPAR3 679/4885LPAR1 773/4885LPAR2 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.