Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.56 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PPM1D | O15297 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22222650 | 0.85 | USP30 (0.62) | USP30HTR6BCHEACKR3KDM4E | |
| SCHEMBL28779687 | 0.85 | USP30 (0.62) | USP30HTR6BCHEACKR3KDM4E | |
| SCHEMBL28779720 | 0.82 | USP30 (0.58) | USP30HTR6BCHEACKR3KDM4E | |
| SCHEMBL28779718 | 0.82 | USP30 (0.58) | USP30HTR6BCHEACKR3KDM4E | |
| SCHEMBL6503017 | 0.82 | USP30 (0.52) | USP30HTR6BCHE | |
| SCHEMBL14744625 | 0.81 | KDM4E (0.52) | USP30HTR6BCHEACKR3KDM4E | |
| SCHEMBL29577021 | 0.80 | USP30 (0.47) | USP30ANO1PARP1HDAC6HDAC4 | |
| SCHEMBL22774219 | 0.80 | USP30 (0.47) | USP30ANO1PARP1HDAC6HDAC4 | |
| SCHEMBL17605512 | 0.79 | USP30 (0.50) | USP30BCHEBRD4PARP1HDAC6 | |
| SCHEMBL17605154 | 0.79 | USP30 (0.50) | USP30BCHEBRD4PARP1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033310-A1 | MODULATORS OF REV-ERB | KAMENECKA THEODORE MARK (US) | 2013-03-07 | — | — | WO | disclosed |