SCHEMBL14740855

SCHEMBL14740855

NCCOCCOCCOCCOCCOCCOCCNC(=O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
LMNA P02545 3/20 0.37
CA2 P00918 7/20 0.36
ALDH1A1 P00352 1/20 0.34
RAB9A P51151 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TLR2 O60603 1/20 0.34
CA12 O43570 4/20 0.33
CA1 P00915 4/20 0.33
CA4 P22748 4/20 0.33
CA9 Q16790 4/20 0.33
CA14 Q9ULX7 4/20 0.33
CTH P32929 1/20 0.33
HRH3 Q9Y5N1 1/20 0.32
EPOR P19235 1/20 0.32
TTR P02766 1/20 0.31
HDAC3 O15379 1/20 0.31
HDAC1 Q13547 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14740911 1.00 SMN1; SMN2 (0.44) SMN1; SMN2MEN1KMT2ALMNACA2
SCHEMBL3802664 1.00 SMN1; SMN2 (0.44) SMN1; SMN2MEN1KMT2ALMNACA2
SCHEMBL14740842 1.00 SMN1; SMN2 (0.44) SMN1; SMN2MEN1KMT2ALMNACA2
SCHEMBL12476057 1.00 SMN1; SMN2 (0.44) SMN1; SMN2MEN1KMT2ALMNACA2
SCHEMBL14740963 1.00 SMN1; SMN2 (0.44) SMN1; SMN2MEN1KMT2ALMNACA2
SCHEMBL1164116 1.00 SMN1; SMN2 (0.44) SMN1; SMN2MEN1KMT2ALMNACA2
SCHEMBL25385243 1.00 SMN1; SMN2 (0.44) SMN1; SMN2MEN1KMT2ALMNACA2
SCHEMBL16756668 1.00 SMN1; SMN2 (0.44) SMN1; SMN2MEN1KMT2ALMNACA2
Hydrochloric Acid SCHEMBL23441155 0.98 SMN1; SMN2 (0.43) SMN1; SMN2MEN1KMT2ALMNACA2
Hydrochloric Acid SCHEMBL23111798 0.98 SMN1; SMN2 (0.43) SMN1; SMN2MEN1KMT2ALMNACA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024077006-A1 FOLLICLE-STIMULATING HORMONE RECEPTOR (FSHR) TARGETED THERAPEUTICS AND USES THEREOF RADIONETICS ONCOLOGY, INC. (US) 2024-04-11 WO disclosed
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 US disclosed
US-20230374007-A1 COMPOUNDS AND THEIR USE IN TREATING CANCER ASTRAZENECA AB (SE) 2023-11-23 US disclosed
WO-2023172889-A1 USE OF CHEMICAL EPIGENETIC MODIFIERS TO MODULATE GENE EXPRESSION THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2023-09-14 WO disclosed
EP-4221756-A1 COMPOUNDS AND THEIR USE IN TREATING CANCER Astrazeneca AB (SE) 2023-08-09 EP disclosed
WO-2023080652-A1 ANDROGEN RECEPTOR DEGRADERS FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER AND USE THEREOF AUTOTAC INC. (KR) 2023-05-11 WO disclosed
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-02-23 US disclosed
WO-2021022076-A1 MOLECULES AND METHODS RELATED TO TREATMENT OF UNCONTROLLED CELLULAR PROLIFERATION ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2021-02-04 WO disclosed
WO-2015106292-A1 BCR-ABL TYROSINE-KINASE LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME COFERON, INC. (US) 2015-07-16 WO disclosed
US-20140243322-A1 BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME COFERON, INC. (US) 2014-08-28 US disclosed
WO-2013033268-A2 BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME COFERON, INC. (US) 2013-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140243322-A1 BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME BRDT, BRD2, BRD4 SMN1; SMN2 4253/4885MEN1 3820/4885KMT2A 408/4885
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 SMN1; SMN2 2621/4885MEN1 3254/4885KMT2A 1342/4885
US-20230374007-A1 COMPOUNDS AND THEIR USE IN TREATING CANCER RARA, RARG, RARB SMN1; SMN2 1457/4885MEN1 153/4885KMT2A 1097/4885
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 SMN1; SMN2 2621/4885MEN1 3254/4885KMT2A 1342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.