Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.71 |
| ▸ | KDR | P35968 | 10/20 | 0.71 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.71 |
| ▸ | TEK | Q02763 | 2/20 | 0.71 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.71 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | LYN | P07948 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | HCK | P08631 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 2/20 | 0.50 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | ABL2 | P42684 | 2/20 | 0.50 |
| ▸ | FRK | P42685 | 2/20 | 0.50 |
| ▸ | MST1R | Q04912 | 2/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138396 | 0.93 | MET (0.82) | METKDRNTRK1TEKNTRK3 | |
| SCHEMBL14742589 | 0.91 | MET (0.59) | METKDRNTRK1TEKNTRK3 | |
| SCHEMBL14742559 | 0.88 | MET (0.58) | METKDRNTRK1TEKNTRK3 | |
| SCHEMBL14742737 | 0.86 | MET (0.64) | METKDRNTRK1TEKNTRK3 | |
| SCHEMBL139578 | 0.86 | KDR (0.71) | METKDRNTRK1TEKNTRK3 | |
| SCHEMBL143451 | 0.85 | MET (0.70) | METKDRNTRK1TEKNTRK3 | |
| SCHEMBL141721 | 0.83 | MET (0.81) | METKDRNTRK1TEKNTRK3 | |
| SCHEMBL143640 | 0.83 | MET (0.78) | METKDRNTRK1TEKNTRK3 | |
| SCHEMBL143778 | 0.83 | MET (0.78) | METKDRNTRK1TEKNTRK3 | |
| SCHEMBL143639 | 0.83 | MET (0.78) | METKDRNTRK1TEKNTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013032797-A2 | OXETANE 3,3-DICARBOXAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME | NEW HOPE R & D BIOSCIENCE, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013032797-A2 | OXETANE 3,3-DICARBOXAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME | NEW HOPE R & D BIOSCIENCE, INC. (US) | 2013-03-07 | — | — | WO | disclosed |