Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL14742725 | 0.95 | MEN1 (0.57) | MEN1GAAKMT2ATDP1MALT1 | |
| Bromide SCHEMBL23458244 | 0.89 | MEN1 (0.51) | MEN1GAAKMT2AMALT1IDO1 | |
| Bromide SCHEMBL16057943 | 0.89 | MEN1 (0.50) | MEN1GAAKMT2ATDP1MALT1 | |
| Bromide SCHEMBL23883206 | 0.85 | GAA (0.47) | MEN1GAAKMT2AMALT1IDO1 | |
| Iodide SCHEMBL16056441 | 0.83 | IDO1 (0.50) | MEN1GAAKMT2AMALT1IDO1 | |
| SCHEMBL6500581 | 0.82 | MEN1 (0.61) | MEN1GAAKMT2ATDP1MALT1 | |
| SCHEMBL6491658 | 0.82 | MEN1 (0.61) | MEN1GAAKMT2ATDP1MALT1 | |
| SCHEMBL6494079 | 0.82 | MEN1 (0.61) | MEN1GAAKMT2ATDP1MALT1 | |
| SCHEMBL24003388 | 0.81 | MEN1 (0.69) | MEN1GAAKMT2ATDP1IDO1 | |
| SCHEMBL9074865 | 0.81 | MEN1 (0.69) | MEN1GAAKMT2ATDP1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751089-B1 | COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H | PROMEGA CORP (US) | 2018-11-14 | — | — | EP | disclosed |
| US-9951372-B2 | Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H | PROMEGA CORPORATION (US) | 2018-04-24 | — | — | US | disclosed |
| US-9273343-B2 | Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H | PROMEGA CORPORATION (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2751089-A1 | COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H | Promega Corporation (US) | 2014-07-09 | — | — | EP | disclosed |
| US-20130130289-A1 | COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H | PROMEGA CORPORATION (US) | 2013-05-23 | — | — | US | disclosed |
| WO-2013033515-A1 | COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H | PROMEGA CORPORATION (US) | 2013-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130130289-A1 | COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H | NQO1, ME2, NADK | MEN1 1916/4885GAA 932/4885KMT2A 3137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.