Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PROKR2 | Q8NFJ6 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.40 |
| ▸ | CLTC | Q00610 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179604 | 0.80 | CHRM5 (0.44) | CHRM5KDM4EMAPTTP53NPBWR1 | |
| SCHEMBL14718403 | 0.80 | CHRM5 (0.44) | CHRM5KDM4EMAPTTP53NPBWR1 | |
| SCHEMBL25433242 | 0.75 | KDM4E (0.48) | CHRM5KDM4EMAPTTP53NPBWR1 | |
| SCHEMBL31208038 | 0.75 | KDM4E (0.48) | CHRM5KDM4EMAPTTP53NPBWR1 | |
| SCHEMBL18074889 | 0.74 | PDE10A (0.50) | CHRM5KDM4EMAPTNPBWR1NPSR1 | |
| SCHEMBL20081377 | 0.73 | BRD4 (0.45) | KDM4EMAPTMAPK1NPSR1LMNA | |
| SCHEMBL14638047 | 0.73 | MAPT (0.41) | KDM4EMAPTMAPK1NPSR1 | |
| SCHEMBL2599468 | 0.72 | PIK3CD (0.42) | TAAR1 | |
| SCHEMBL25432242 | 0.70 | KDM4E (0.44) | KDM4EMAPTTP53LMNAP2RX4 | |
| SCHEMBL16584828 | 0.69 | PIK3CD (0.42) | MAPTTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751093-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | Infinity Pharmaceuticals, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013032591-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS INC. (US) | 2013-03-07 | — | — | WO | disclosed |