SCHEMBL14743298

SCHEMBL14743298

N#Cc1ccc(Oc2ccc(-c3nc(N[C@H](C=O)CN)cc(C(N)=O)n3)cc2)nc1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 20/20 0.73
SCN9A Q15858 20/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14744036 1.00 FPR2 (0.73) FPR2SCN9A
SCHEMBL14743673 0.88 SCN9A (0.71) FPR2SCN9A
SCHEMBL14743808 0.87 FPR2 (0.72) FPR2SCN9A
SCHEMBL14742363 0.85 FPR2 (0.72) FPR2SCN9A
SCHEMBL14743176 0.85 FPR2 (0.72) FPR2SCN9A
SCHEMBL14743165 0.85 SCN9A (0.73) FPR2SCN9A
SCHEMBL16013806 0.85 SCN9A (0.73) FPR2SCN9A
SCHEMBL14744033 0.84 FPR2 (1.00) FPR2SCN9A
SCHEMBL14743300 0.84 FPR2 (1.00) FPR2SCN9A
SCHEMBL16012638 0.84 FPR2 (0.56) FPR2SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013030665-A1 PYRIMIDINES AS SODIUM CHANNEL BLOCKERS PURDUE PHARMA L.P. (US) 2013-03-07 WO disclosed