SCHEMBL14743997

SCHEMBL14743997

COc1ccc(NC(=O)C[S+]([O-])c2ccc(F)c(F)c2)cc1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.50
L3MBTL1 Q9Y468 2/20 0.48
SMN1; SMN2 Q16637 3/20 0.47
HTT P42858 2/20 0.47
NPC1 O15118 2/20 0.47
MAPT P10636 2/20 0.47
RAB9A P51151 2/20 0.47
KDM4E B2RXH2 2/20 0.46
POLB P06746 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
LMNA P02545 1/20 0.45
GAA P10253 1/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14743333 0.90 SMN1; SMN2 (0.59) ALDH1A1L3MBTL1SMN1; SMN2HTTNPC1
SCHEMBL14743335 0.90 SMN1; SMN2 (0.59) ALDH1A1L3MBTL1SMN1; SMN2HTTNPC1
SCHEMBL14744419 0.90 SMN1; SMN2 (0.59) ALDH1A1L3MBTL1SMN1; SMN2HTTNPC1
SCHEMBL14743109 0.84 CYP1A2 (0.48) ALDH1A1L3MBTL1SMN1; SMN2HTTNPC1
SCHEMBL14743319 0.84 CYP1A2 (0.48) ALDH1A1L3MBTL1SMN1; SMN2HTTNPC1
SCHEMBL14743108 0.84 CYP1A2 (0.48) ALDH1A1L3MBTL1SMN1; SMN2HTTNPC1
SCHEMBL14743445 0.83 NPC1 (0.54) ALDH1A1L3MBTL1SMN1; SMN2HTTNPC1
SCHEMBL14743287 0.82 MTNR1B (0.54) ALDH1A1L3MBTL1SMN1; SMN2HTTNPC1
SCHEMBL14743203 0.82 KMT2A (0.53) ALDH1A1L3MBTL1SMN1; SMN2HTTNPC1
SCHEMBL14744393 0.81 MEN1 (0.49) ALDH1A1L3MBTL1SMN1; SMN2HTTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2758370-A1 PARP INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2014-07-30 EP claimed
WO-2013030205-A1 PARP INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2013-03-07 WO claimed
EP-2758370-A1 PARP INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2014-07-30 EP disclosed
WO-2013030205-A1 PARP INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2013-03-07 WO disclosed