Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 7/20 | 0.47 |
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | CA12 | O43570 | 6/20 | 0.47 |
| ▸ | CA9 | Q16790 | 6/20 | 0.47 |
| ▸ | STK17B | O94768 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL754326 | 1.00 | MEN1 (0.66) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL751969 | 0.90 | MEN1 (0.56) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL6327615 | 0.85 | MEN1 (0.64) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL6535051 | 0.85 | MEN1 (0.68) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL20285754 | 0.84 | MEN1 (0.72) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL18085409 | 0.83 | MEN1 (0.66) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL20471828 | 0.83 | MEN1 (0.70) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL12650094 | 0.82 | MEN1 (0.74) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL16256540 | 0.82 | EPHX1 (0.50) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL22574596 | 0.82 | MEN1 (0.64) | MEN1GAAKMT2ATDP1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |