Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14738054 | 0.87 | DGAT1 (0.33) | DGAT1EGLN1 | |
| SCHEMBL14738039 | 0.86 | MAPK1 (0.41) | DGAT1 | |
| SCHEMBL14743870 | 0.84 | DGAT1 (0.32) | DGAT1KLKB1EGLN1 | |
| SCHEMBL14752058 | 0.81 | MAP2K4 (0.38) | DGAT1 | |
| SCHEMBL14743741 | 0.80 | KLKB1 (0.33) | DGAT1KLKB1 | |
| SCHEMBL14737531 | 0.80 | MAP2K4 (0.41) | DGAT1KLKB1 | |
| SCHEMBL14747115 | 0.79 | SYK (0.49) | DGAT1 | |
| SCHEMBL14737990 | 0.79 | — | — | |
| SCHEMBL14743918 | 0.79 | DGAT1 (0.34) | DGAT1KLKB1 | |
| SCHEMBL14737441 | 0.78 | SYK (0.33) | DGAT1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |