Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14736829 | 0.80 | SYK (0.66) | SYKCYP2D6DYRK1A | |
| SCHEMBL14738398 | 0.78 | SYK (0.46) | SYKCYP2D6 | |
| SCHEMBL14737166 | 0.77 | SYK (0.49) | SYKCYP2D6 | |
| SCHEMBL14738014 | 0.72 | SYK (0.57) | SYKCYP2D6 | |
| SCHEMBL14751448 | 0.72 | SYK (0.36) | SYKCYP2D6 | |
| SCHEMBL14751578 | 0.72 | SYK (0.39) | SYK | |
| SCHEMBL14737639 | 0.71 | DHPS (0.38) | SYKCYP2D6 | |
| SCHEMBL18535020 | 0.71 | — | — | |
| SCHEMBL14737605 | 0.71 | SYK (0.35) | SYK | |
| SCHEMBL14737403 | 0.70 | SYK (0.36) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |