SCHEMBL14744467

SCHEMBL14744467

Cc1ccc(N)cc1-c1ccc(Cl)cc1Cl

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 1/20 0.66
CYP3A4 P08684 3/20 0.53
HSP90AA1 P07900 2/20 0.46
HSP90AB1 P08238 2/20 0.46
ITGB2 P05107 1/20 0.44
ICAM1 P05362 1/20 0.44
ITGAL P20701 1/20 0.44
HSD11B1 P28845 1/20 0.44
ALDH1A1 P00352 2/20 0.43
CRHR1 P34998 2/20 0.42
CASP1 P29466 2/20 0.42
TSHR P16473 2/20 0.42
AMY1A P0DUB6 1/20 0.41
AHR P35869 1/20 0.41
KDM4E B2RXH2 1/20 0.41
MGAM O43451 1/20 0.41
GAA P10253 1/20 0.41
SI P14410 1/20 0.41
RAB9A P51151 1/20 0.41
MGAM2 Q2M2H8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14744510 0.85 PLA2G7 (0.66) PLA2G7CYP3A4ITGB2ICAM1ITGAL
SCHEMBL14054914 0.84 ITGB2 (0.59) PLA2G7CYP3A4HSP90AA1HSP90AB1ITGB2
SCHEMBL14056729 0.83 CYP3A4 (0.55) PLA2G7CYP3A4HSP90AA1HSP90AB1ITGB2
SCHEMBL21021238 0.82 PLA2G7 (0.62) PLA2G7CYP3A4HSD11B1ALDH1A1CASP1
SCHEMBL18430945 0.80 PLA2G7 (0.75) PLA2G7CYP3A4ALDH1A1CASP1TSHR
SCHEMBL30092397 0.79 PLA2G7 (0.65) PLA2G7CYP3A4ALDH1A1CASP1TSHR
SCHEMBL31607621 0.79 PLA2G7 (0.65) PLA2G7CYP3A4ALDH1A1CASP1TSHR
SCHEMBL8848693 0.79 PLA2G7 (0.65) PLA2G7CYP3A4ALDH1A1CASP1TSHR
Hydrochloric Acid SCHEMBL6574537 0.79 TSHR (0.54) PLA2G7CYP3A4HSP90AA1HSP90AB1ITGB2
SCHEMBL15292824 0.77 PLA2G7 (0.55) PLA2G7CYP3A4ALDH1A1CASP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013029338-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2013-03-07 WO disclosed