⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14745206 | 0.89 | MCL1 (0.30) | — | |
| SCHEMBL13448722 | 0.70 | HTR2A (0.42) | — | |
| SCHEMBL14745400 | 0.68 | USP30 (0.39) | — | |
| SCHEMBL31748498 | 0.66 | PNMT (0.41) | — | |
| SCHEMBL15265443 | 0.63 | SLC22A12 (0.34) | — | |
| SCHEMBL15265437 | 0.63 | SLC22A12 (0.34) | — | |
| SCHEMBL22128430 | 0.61 | JAK3 (0.32) | — | |
| SCHEMBL26683570 | 0.60 | HTR2A (0.46) | — | |
| SCHEMBL4041138 | 0.57 | HTR2A (0.36) | — | |
| SCHEMBL14745398 | 0.57 | KRAS (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409905-B2 | Antibacterial compounds and methods for use | PTC THERAPEUTICS, INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-20150038437-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2015-02-05 | — | — | US | disclosed |
| EP-2750504-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033258-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |