Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138439 | 0.84 | PRKACA (0.50) | HTR2CHTR2BPRKACAPRKACGPRKACB | |
| Hydrochloric Acid SCHEMBL12804515 | 0.83 | PRKACA (0.49) | HTR2CHTR2BPRKACAPRKACGPRKACB | |
| SCHEMBL29537759 | 0.78 | ADRA1A (0.43) | HTR2CHTR2BADRA1ATSHRDRD4 | |
| SCHEMBL1499246 | 0.78 | ADRA1A (0.43) | HTR2CHTR2BADRA1ATSHRDRD4 | |
| SCHEMBL28640497 | 0.76 | HTR2C (0.35) | HTR2CHTR2BPRKACAPRKACGPRKACB | |
| SCHEMBL27932733 | 0.75 | KDM1A (0.34) | HTR2CHTR2BPRKACAPRKACGPRKACB | |
| SCHEMBL9556375 | 0.70 | MAPKAPK2 (0.38) | PRKACAPRKACGPRKACBADRA1ATSHR | |
| SCHEMBL28771523 | 0.70 | PRKACA (0.49) | HTR2CHTR2BPRKACAPRKACGPRKACB | |
| SCHEMBL11632150 | 0.70 | PRKACA (0.55) | HTR2CHTR2BPRKACAPRKACGPRKACB | |
| SCHEMBL20592264 | 0.69 | TSHR (0.39) | HTR2CHTR2BADRA1ATSHRDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751109-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033569-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2013-03-07 | — | — | WO | disclosed |