Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.60 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29745032 | 0.98 | GAA (0.73) | GAAMAPTKDM4EPTK2BMAPK1 | |
| SCHEMBL76547 | 0.98 | GAA (0.73) | GAAMAPTKDM4EPTK2BMAPK1 | |
| SCHEMBL3935104 | 0.91 | MAPT (0.65) | GAAMAPTKDM4EPTK2BMAPK1 | |
| SCHEMBL30565926 | 0.91 | MAPT (0.65) | GAAMAPTKDM4EPTK2BMAPK1 | |
| SCHEMBL29666122 | 0.85 | MAPT (0.57) | GAAMAPTKDM4EPTK2BMAPK1 | |
| SCHEMBL31173630 | 0.84 | MAPT (0.60) | GAAMAPTKDM4EPTK2BMAPK1 | |
| SCHEMBL20475482 | 0.84 | MAPT (0.60) | GAAMAPTKDM4EPTK2BMAPK1 | |
| SCHEMBL519972 | 0.83 | GAA (0.69) | GAAMAPTKDM4EPTK2BMAPK1 | |
| SCHEMBL30900439 | 0.83 | GAA (0.64) | GAAMAPTKDM4EPTK2BMAPK1 | |
| SCHEMBL6150891 | 0.83 | GAA (0.69) | GAAMAPTKDM4EPTK2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751127-B1 | CYCLOSPORIN DERIVATIVES | MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V (DE) | 2016-07-27 | — | — | EP | disclosed |
| EP-2751127-A1 | CYCLOSPORIN DERIVATIVES | Max-Planck-Gesellschaft zur Förderung der Wissenschaften (DE) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013030208-A1 | CYCLOSPORIN DERIVATIVES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2013-03-07 | — | — | WO | disclosed |