Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 18/20 | 0.66 |
| ▸ | RAB9A | P51151 | 18/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 18/20 | 0.66 |
| ▸ | NPC1 | O15118 | 17/20 | 0.66 |
| ▸ | ATM | Q13315 | 2/20 | 0.66 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.51 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.50 |
| ▸ | RELA | Q04206 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CCR4 | P51679 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14742545 | 0.83 | NPC1 (0.94) | MEN1RAB9AKMT2ANPC1ATM | |
| SCHEMBL14746241 | 0.80 | NPC1 (0.67) | MEN1RAB9AKMT2ANPC1ATM | |
| SCHEMBL14758393 | 0.79 | NPC1 (0.65) | MEN1RAB9AKMT2ANPC1ATM | |
| SCHEMBL14746457 | 0.78 | NPC1 (0.63) | MEN1RAB9AKMT2ANPC1ATM | |
| SCHEMBL18029575 | 0.77 | NPC1 (0.94) | MEN1RAB9AKMT2ANPC1ATM | |
| SCHEMBL29427807 | 0.77 | NPC1 (0.94) | MEN1RAB9AKMT2ANPC1ATM | |
| SCHEMBL4562048 | 0.76 | MAPT (0.71) | MEN1RAB9AKMT2ANPC1MAPT | |
| SCHEMBL5238308 | 0.74 | NPC1 (0.74) | MEN1RAB9AKMT2ANPC1SENP8 | |
| SCHEMBL1821894 | 0.74 | ALOX5 (0.79) | MEN1RAB9AKMT2ANPC1MAPT | |
| SCHEMBL14746044 | 0.74 | NPC1 (0.58) | MEN1RAB9AKMT2ANPC1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140329863-A1 | NOVEL ANTIPRION COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140329863-A1 | NOVEL ANTIPRION COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140329863-A1 | NOVEL ANTIPRION COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-06 | — | — | US | disclosed |
| WO-2013033037-A2 | NOVEL ANTIPRION COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013033037-A2 | NOVEL ANTIPRION COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329863-A1 | NOVEL ANTIPRION COMPOUNDS | PRNP, PSEN1, PSEN2 | MEN1 4510/4885RAB9A 1779/4885KMT2A 4582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.